RESEARCH Associate Professor

电话: 757-683-7021

电子邮件: s2guo@bayankolsaatleri.com

地址: IRP 2, 4211 Monarch Way, Norfolk, VA, 23508

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Education

Postdoctoral fellow, Old Dominion University, 2009-2012

Postdoctoral fellow, Virginia Commonwealth University, 2007-2009

Postdoctoral fellow, University Alabama at Birmingham, 2005-2007

M.S. Academy of 军事 Medical Sciences, 1997

M.D. Zhejiang University School of Medicine, 1991

实验室成员

卡洛周，实验室技术员

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RESEARCH Description

The research efforts in the Guo laboratory include (1) the development of enhanced electric pulse (EP) technologies for tumor eradication, (2) the elucidation of mechanisms of immune responses induced by nanosecond electric pulse (nsEP) tumor ablation, and (3) the development of EP based combination approaches for cancer therapy. Long-term goal is to facilitate safe and effective EP technology-based cancer therapies for clinical applications.

By investigating the mechanisms of nsEP tumor ablation, Dr. Guo's group demonstrated that a single nsEP treatment can trigger multiple actions nullifying the immunosuppression in tumor so antitumor immunity can be induced. This feature of nsEPs could be utilized to develop a novel in situ vaccination strategy as cancer immunotherapy, especially for poorly immunogenic cancers including breast cancer and pancreatic cancer.

最靠谱的网赌软件

Call for Papers- Special Issue in Frontiers in Oncology

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Most relevant publications

1. 郭先生, Smeltz RB, Nanajian A, Heller R. (2021). IL‐15/IL‐15Rα heterodimeric complex as cancer immunotherapy in murine breast cancer models. 前面Immunol. 2021 Feb 8;11: 614667.
2. 郭年代, Jing Y, Burcus NI, Lassiter BP, Tanaz R, Heller R, and Beebe SJ. (2018). Nano-pulse stimulation induces potent immune responses, eradicating local breast cancer while reducing distant metastases. 恶性肿瘤. 142(3): 629-40.
3. 郭年代, Burcus NI, Hornef J, Jing Y, Jiang C, Heller R, and Beebe SJ. (2018). Nano-pulse stimulation for the treatment of pancreatic cancer and the changes in immune profile. 癌症 (巴塞尔). 10(7): 217.
   
4. Edelblute CM, Hornef J, Burcus NI, Norman, T, Beebe SJ, Schoenbach K, Heller R, and 郭年代. (2017). Controllable moderate heating enhances the therapeutic efficacy of irreversible electroporation for pancreatic cancer. Scientific Reports. 7(1): 11767.
5. 郭先生, 捐赠 A, Basu G, Lundberg C, Heller LC, and Heller R. (2011). Electro-gene transfer to skin using a noninvasive multielectrode array. J控制释放. 151(3): 256-62.

奖项及荣誉

• 2019 Young Investigator Award, Frank Reidy RESEARCH Center for 生物, ODU