P教授. 托马斯游标 wins the Frank Reidy Award for Outstanding Achievements in 生物

P. 托马斯游标和Dr. Federica Castellani教授. Esin索泽

今年教授. P. 托马斯游标 from 最靠谱的网赌软件 and 教授. Marie Pierre Rols from University of Toulouse were awarded the 2021 and 2022 Frank Reidy Awards for Outstanding Achievements in 生物, 分别. The awards were presented in October at the 4th World Congress on Electroporation and Pulsed Electric Fields in Biology, 医学, and Food and Environmental Technologies in Copenhagen.

成立于2010年 Frank Reidy Award for Outstanding Achievements in 生物 recognizes a scientist working in the field of bioelectrics who has made significant scientific contributions to the fields of electrical effects on cells and tissue.

AboutP. 托马斯游标

教授. P. 托马斯游标 is a world-renowned pioneer scientist and teacher whose critical scientific work, 结合了他的工作理念, 启发, and supported many others in the bioelectrics community over the past two decades.

教授. Vernier has been a pioneer in nanosecond pulsed electric fields (nsPEF) stimulation and permeabilization research. His unique body of work in bioelectrics research spans experimental studies and molecular simulation findings that elucidated critical fundamental biophysics underlying bioelectrics and electroporation over the last two decades.

In several groundbreaking studies, in parallel with A. 帕克霍莫夫和J. 韦弗的团队，韦弗教授. Vernier demonstrated that nsPEF could open nanopores in the cell plasma membrane and intracellular membranes. This work further led to 他的团队 demonstrating intracellular calcium release and mitochondrial membrane depolarization by nanosecond pulses. Both processes are critical in many biochemical processes in cell function and can be utilized to modulate cellular functionality. His work 启发 and expanded the field of electroporation both in applications of cancer therapy and electrostimulation of excitable cells.

教授. Vernier was among the first scientists to apply molecular dynamic simulation (MDS) to study the molecular basis of electroporation thus allowing us to "see" molecules in action on a time and distance scale that is not possible experimentally. 使用MDS, 他的团队 tracked and defined stages of pore formation and annihilation dynamics and identified the reorganization of interfacial water as the driving event in electropores formation. His team demonstrated that the externalization of the phospholipid phosphatidylserine (PS), normally located on the inner side of the plasma membrane, 是一个明显的, electropermeabilization-related process separate from the PS externalization associated with apoptosis.

教授. Vernier work both in MDS and his collaborative studies in electrostimulation with very short nanosecond pulses were further expanded in his contribution within the framework of a multidisciplinary research initiative (MURI) starting in 2014. 这些最近的RESEARCH, 与同事Esin Sözer和Josh Zimmerberg合作, led to the first time-dependent measurements of electroporative transport using giant unilamellar vesicles (GUVs) exposed to nsPEF showing consistency with MDS results and significant difference from cellular exposures. These were also the first experimental results consistent with the MDS-based lifetime of purely lipid electropores to be less than 50 ns.

最近，教授. Vernier started to study the immune stimulatory effects of electroporation, 这是一个仍然知之甚少的新维度. Being among the few groups studying the effects of electroporation on immune cells, 他的团队, including colleagues Claudia Muratori and Flavia Mazzarda, found that the damage created by nanosecond pulses is sensed intracellularly by the immune platform known as the inflammasome. Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals

In addition to his outstanding scientific accomplishments, 教授. Vernier以他的细节而闻名, 然而清晰的生物物理学在说话, his training of many young scientists both in his lab as well as in international initiatives such as the electroporation schools organized in Ljubljana and Norfolk, and his collaborations with a wide range of national and international labs. His unique ability as a scientist and teacher partly comes from his broad training and degrees in Biology, 化学, 电气工程, in addition to his industrial engineering experience. He is widely respected and applauded for his scientific work and is an example of caring and enthusiastic support to multiple generations of researchers in many countries.